Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy

Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy

The enzyme glutamine synthetase (GS), also referred to as glutamate ammonia ligase, is abundant in astrocytes and catalyzes the conversion of ammonia and glutamate to glutamine. Deficiency or dysfunction of astrocytic GS in discrete brain regions have been associated with several types of epilepsy,...

Full description

Bibliographic Details
Main Authors: Mani Ratnesh S. Sandhu, Benjamin F. Gruenbaum, Shaun E. Gruenbaum, Roni Dhaher, Ketaki Deshpande, Melissa C. Funaro, Tih-Shih W. Lee, Hitten P. Zaveri, Tore Eid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neurology
Subjects:
epilepsy
epileptogenesis
glutamine synthetase
astrocyte
epilepsy network
mesial temporal lobe epilepsy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.665334/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.665334/full

Similar Items