The REST remodeling complex protects genomic integrity during embryonic neurogenesis

The REST remodeling complex protects genomic integrity during embryonic neurogenesis

The timely transition from neural progenitor to post-mitotic neuron requires down-regulation and loss of the neuronal transcriptional repressor, REST. Here, we have used mice containing a gene trap in the Rest gene, eliminating transcription from all coding exons, to remove REST prematurely from neu...

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Bibliographic Details
Main Authors: Tamilla Nechiporuk, James McGann, Karin Mullendorff, Jenny Hsieh, Wolfgang Wurst, Thomas Floss, Gail Mandel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
transcription factor
repression
genomic instability
neurogenesis
REST complex
knockout animal
Online Access:https://elifesciences.org/articles/09584

Internet

https://elifesciences.org/articles/09584

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