USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer

The Hippo signaling pathway is an evolutionarily conserved pathway that was initially discovered in <i>Drosophila melanogaster </i>and was later found to have mammalian orthologues. The key effector proteins in this pathway, YAP/TAZ, are often dysregulated in cancer, leading to a high de...

Full description

Bibliographic Details
Main Authors: Ashley Mussell, He Shen, Yanmin Chen, Michalis Mastri, Kevin H. Eng, Wiam Bshara, Costa Frangou, Jianmin Zhang
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
TAZ
Online Access:https://www.mdpi.com/2072-6694/12/11/3090