Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD.

Overexpression of chitinase 3-like 1/YKL-40 in lung-specific IL-18-transgenic mice, smokers and COPD.

We analyzed the lung mRNA expression profiles of a murine model of COPD developed using a lung-specific IL-18-transgenic mouse. In this transgenic mouse, the expression of 608 genes was found to vary more than 2-fold in comparison with control WT mice, and was clustered into 4 groups. The expression...

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Bibliographic Details
Main Authors: Yuki Sakazaki, Tomoaki Hoshino, Satoko Takei, Masanori Sawada, Hanako Oda, Shin-ichi Takenaka, Haruki Imaoka, Kazuko Matsunaga, Toshio Ota, Yuzuru Abe, Ichiro Miki, Kiminori Fujimoto, Tomotaka Kawayama, Seiya Kato, Hisamichi Aizawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3168485?pdf=render

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http://europepmc.org/articles/PMC3168485?pdf=render

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