Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model

Major motor and gait deficits with sexual dimorphism in a Shank3 mutant mouse model

Abstract Background Contrasting findings were reported in several animal models with a Shank3 mutation used to induce various autism spectrum disorder (ASD) symptoms. Here, we aimed at investigating behavioral, cellular, and molecular consequences of a C-terminal (frameshift in exon 21) deletion in...

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Bibliographic Details
Main Authors: Emmanuel Matas, Alexandre Maisterrena, Mathieu Thabault, Eric Balado, Maureen Francheteau, Anais Balbous, Laurie Galvan, Mohamed Jaber
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Autism
Subjects:
Gait
Sociability
Motor coordination
Cerebellum
Crus I
Crus II
Online Access:https://doi.org/10.1186/s13229-020-00412-8

Internet

https://doi.org/10.1186/s13229-020-00412-8

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