The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium

The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium

Abstract Background Epidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on acetaldehyde metabolism, the association of rs...

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Bibliographic Details
Main Authors: Tomotaka Ugai, Roger L. Milne, Hidemi Ito, Kristan J. Aronson, Manjeet K. Bolla, Tsun Chan, Ching W. Chan, Ji‐Yeob Choi, Don M. Conroy, Joe Dennis, Alison M. Dunning, Douglas F. Easton, Valerie Gaborieau, Anna Gonzalez‐Neira, Mikael Hartman, Catherine S. Healey, Motoki Iwasaki, Esther M. John, Daehee Kang, Sung‐Won Kim, Ava Kwong, Artitaya Lophatananon, Kyriaki Michailidou, Nur Aishah Mohd Taib, Kenneth Muir, Sue K. Park, Paul D. P. Pharoah, Suleeporn Sangrajrang, Chen‐Yang Shen, Xiao‐Ou Shu, John J. Spinelli, Soo H. Teo, Daniel C. Tessier, Chiu‐Chen Tseng, Shoichiro Tsugane, Daniel Vincent, Qin Wang, Anna H. Wu, Pei‐Ei Wu, Wei Zheng, Keitaro Matsuo
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
acetaldehyde
alcohol drinking
aldehyde dehydrogenase‐2
breast cancer
single nucleotide polymorphism
Online Access:https://doi.org/10.1002/mgg3.707

Internet

https://doi.org/10.1002/mgg3.707

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