A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnology reagents as well as a new cl...

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Bibliographic Details
Main Authors: Ananya Paul, Pu Guo, David W. Boykin, W. David Wilson
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
DNA G·C base pair recognition
mixed base pair DNA sequences
sequence selectivity
heterocyclic diamidine
σ-hole
thiophene-N-methylbenzimidazole
benzimidazole
aza-benzimidazole
biosensor
Online Access:http://www.mdpi.com/1420-3049/24/5/946

Internet

http://www.mdpi.com/1420-3049/24/5/946

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