Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner

Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner

Cysteine cathepsins are critical components of the adaptive immune system involved in the generation of epitopes for presentation on human leukocyte antigen (HLA) molecules and have been implicated in degradation of autoantigens. Immunoglobulin variable regions with somatic mutations and random comp...

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Bibliographic Details
Main Authors: Rune Alexander Høglund, Silje Bøen Torsetnes, Andreas Lossius, Bjarne Bogen, E. Jane Homan, Robert Bremel, Trygve Holmøy
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
cathepsin
endosome
endolysosome
protease
b cell
antigen presenting cell
bioinformatics
in silico model
protease cleavage prediction
Online Access:https://www.mdpi.com/1422-0067/20/19/4843

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https://www.mdpi.com/1422-0067/20/19/4843

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