Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.

Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.

The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of viral sequences from HIV-1 infe...

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Bibliographic Details
Main Authors: James I Mullins, Laura Heath, James P Hughes, Jessica Kicha, Sheila Styrchak, Kim G Wong, Ushnal Rao, Alexis Hansen, Kevin S Harris, Jean-Pierre Laurent, Deyu Li, Jeffrey H Simpson, John M Essigmann, Lawrence A Loeb, Jeffrey Parkins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3021505?pdf=render

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http://europepmc.org/articles/PMC3021505?pdf=render

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