Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway

Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway

A heterozygous point mutation of p53 gene at codon 280 from AGA to ACA (R280T) frequently occurs in nasopharyngeal carcinoma (NPC) cell lines, and about 10% NPC tissues. However, the role of this mutation in the pathogenesis of NPC remains unclear. In this study, we generated p53 knockout (KO) NPC c...

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Bibliographic Details
Main Authors: Zhen-Qi Qin, Qi-Guang Li, Hong Yi, Shan-Shan Lu, Wei Huang, Zhuo-Xian Rong, Yao-Yun Tang, Zhi-Qiang Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Oncology
Subjects:
nasopharyngeal carcinoma
p53
R280T mutation
oncogenicity
Akt
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00104/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00104/full

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