CRISPRa-mediated FOXP3 gene upregulation in mammalian cells

CRISPRa-mediated FOXP3 gene upregulation in mammalian cells

Abstract Background Forkhead box P3+ (FOXP3 +) regulatory T cells (Tregs) are a subset of lymphocytes, critical for the maintenance of immune homeostasis. Loss-of-function mutations of the FOXP3 gene in animal models and humans results in loss of differentiation potential into Treg cells and are res...

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Bibliographic Details
Main Authors: Vida Forstnerič, Irena Oven, Jernej Ogorevc, Duško Lainšček, Arne Praznik, Tina Lebar, Roman Jerala, Simon Horvat
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell & Bioscience
Subjects:
CRISPR
FOXP3
Transcription regulation
Online Access:http://link.springer.com/article/10.1186/s13578-019-0357-0

Internet

http://link.springer.com/article/10.1186/s13578-019-0357-0

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