Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non–Small Cell Lung Cancer

Loss of basement membrane (BM) integrity is typically associated with cancer. Nidogen-1 is an essential component of the BM. Nidogen-1 is a substrate for cathepsin-S (CatS) which is released into the tumor microenvironment. Measuring nidogen-1 degraded by CatS may therefore have biomarker potential...

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Bibliographic Details
Main Authors: Nicholas Willumsen, Cecilie L. Bager, Diana J. Leeming, Anne-Christine Bay-Jensen, Morten A. Karsdal
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616302342