scNPF: an integrative framework assisted by network propagation and network fusion for preprocessing of single-cell RNA-seq data

scNPF: an integrative framework assisted by network propagation and network fusion for preprocessing of single-cell RNA-seq data

Abstract Background Single-cell RNA-sequencing (scRNA-seq) is fast becoming a powerful tool for profiling genome-scale transcriptomes of individual cells and capturing transcriptome-wide cell-to-cell variability. However, scRNA-seq technologies suffer from high levels of technical noise and variabil...

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Bibliographic Details
Main Authors: Wenbin Ye, Guoli Ji, Pengchao Ye, Yuqi Long, Xuesong Xiao, Shuchao Li, Yaru Su, Xiaohui Wu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Genomics
Subjects:
Single cell RNA-sequencing
Dropout imputation
Similarity measurement
Cell type clustering
Network propagation
Online Access:http://link.springer.com/article/10.1186/s12864-019-5747-5

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http://link.springer.com/article/10.1186/s12864-019-5747-5

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