Induction of Immunological Tolerance to Islet Allografts

T-cell dependent activation of resting B cells involves the interaction of gp39 on T cells with its receptor, CD40, on B cells. We administered either a combination of T-cell-depleted splenic lymphocytes and anti-gp39 monoclonal antibody or antibody alone to establish islet allografts in mice withou...

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Bibliographic Details
Main Authors: Aldo A. Rossini M.D., David C. Parker, Nancy E. Phillips, Fiona H. Durie, Randolph J. Noelle, John P. Mordes, Dale L. Greiner
Format: Article
Language:English
Published: SAGE Publishing 1996-01-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979600500109