In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

Transthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both cleaved and full-length TTR, particularly in the...

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Bibliographic Details
Main Authors: Filipa Bezerra, Christoph Niemietz, Hartmut H. J. Schmidt, Andree Zibert, Shuling Guo, Brett P. Monia, Paula Gonçalves, Maria João Saraiva, Maria Rosário Almeida
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
transthyretin
SerpinA1
ATTR amyloidosis
TTR proteolysis
plasmin
Online Access:https://www.mdpi.com/1422-0067/22/17/9488

Internet

https://www.mdpi.com/1422-0067/22/17/9488

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