Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients

Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients

Purpose: This study was performed to investigate the effects of common polymorphisms in CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects of bisoprolol in hypertensive Chinese patients.Methods: One hundred patients with essential hypertension were treated with open-label bi...

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Bibliographic Details
Main Authors: Sze Wa Chan, Tanya T. W. Chu, Chung Shun Ho, Alice P. S. Kong, Brian Tomlinson, Weiwei Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Medicine
Subjects:
bisoprolol
blood pressure
CYP2D6
CYP3A5
pharmacokinetics
polymorphisms
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.683498/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.683498/full

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