A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by <i>Streptomyces Clavuligerus</i>

A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by <i>Streptomyces Clavuligerus</i>

<i>Streptomyces clavuligerus</i> is a filamentous Gram-positive bacterial producer of the β-lactamase inhibitor clavulanic acid. Antibiotics biosynthesis in the <i>Streptomyces</i> genus is usually triggered by nutritional and environmental perturbations. In this work, a new...

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Bibliographic Details
Main Authors: David Gómez-Ríos, Victor A. López-Agudelo, Howard Ramírez-Malule, Peter Neubauer, Stefan Junne, Silvia Ochoa, Rigoberto Ríos-Estepa
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Microorganisms
Subjects:
<i>Streptomyces</i>
genome-scale model
flux balance analysis
clavulanic acid
<i>Streptomyces clavuligerus</i>
TCA cycle
Online Access:https://www.mdpi.com/2076-2607/8/9/1255

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https://www.mdpi.com/2076-2607/8/9/1255

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