Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Abstract Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in clinically relevant patient-derived...

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Bibliographic Details
Main Authors: Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Biomarker Research
Subjects:
PDX models of acute leukemia
Inducible transgene expression
KLF4
Azacitidine
Online Access:http://link.springer.com/article/10.1186/s40364-020-00226-z

Internet

http://link.springer.com/article/10.1186/s40364-020-00226-z

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