Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

Abstract The contributions of maternal diet and obesity in shaping offspring microbiome remain unclear. Here we employed a mouse model of maternal diet-induced obesity via high-fat diet feeding (HFD, 45% fat calories) for 12 wk prior to conception on offspring gut microbial ecology. Male and female...

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Bibliographic Details
Main Authors: Umesh D. Wankhade, Ying Zhong, Ping Kang, Maria Alfaro, Sree V. Chintapalli, Brian D. Piccolo, Kelly E. Mercer, Aline Andres, Keshari M. Thakali, Kartik Shankar
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Scientific Reports
Subjects:
Maternal Diet
Female Offspring
Microbiome
Male Offspring
Serum Bile Acid Concentrations
Online Access:https://doi.org/10.1038/s41598-018-34453-0

Internet

https://doi.org/10.1038/s41598-018-34453-0

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