Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1

Soluble Epoxide Hydrolase Inhibitors Regulate Ischemic Arrhythmia by Targeting MicroRNA-1

Background: Soluble epoxide hydrolase inhibitors (sEHis) inhibit the degradation of epoxyeicosatrienoic acids (EETs) in cells, and EETs have antiarrhythmic effects. Our previous experiments confirmed that t-AUCB, a preparation of sEHis, inhibited ischemic arrhythmia by negatively regulating microRNA...

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Bibliographic Details
Main Authors: Yanying Chen, Qiong Liu, Tian Yang, Li Shen, Danyan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
miR-1
EETs
t-AUCB
SRF
PI3K/Akt/GSK3β pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.717119/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.717119/full

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