Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness

Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness

Abstract Objective Cardiac diastolic dysfunction (DD) and arterial stiffness are early manifestations of obesity-associated prediabetes, and both serve as risk factors for the development of heart failure with preserved ejection fraction (HFpEF). Since the incidence of DD and arterial stiffness are...

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Bibliographic Details
Main Authors: Annayya R. Aroor, Srinivas Mummidi, Juan Carlos Lopez-Alvarenga, Nitin Das, Javad Habibi, Guanghong Jia, Guido Lastra, Bysani Chandrasekar, Vincent G. DeMarco
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cardiovascular Diabetology
Subjects:
Obesity
Diabetes
Diastolic dysfunction
Neprilysin inhibition
Online Access:https://doi.org/10.1186/s12933-021-01270-1

Internet

https://doi.org/10.1186/s12933-021-01270-1

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