Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.

Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor.

A large genomic deletion in human cardiac ryanodine receptor (RYR2) gene has been detected in a number of unrelated families with various clinical phenotypes, including catecholaminergic polymorphic ventricular tachycardia (CPVT). This genomic deletion results in an in-frame deletion of exon-3 (Ex3-...

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Bibliographic Details
Main Authors: Yingjie Liu, Ruiwu Wang, Bo Sun, Tao Mi, Jingqun Zhang, Yongxin Mu, Ju Chen, Michael J Bround, James D Johnson, Anne M Gillis, S R Wayne Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990712?pdf=render

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http://europepmc.org/articles/PMC3990712?pdf=render

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