The role of mitochondrial DNA large deletion for the development of presbycusis in Fischer 344 rats

Age-related hearing loss, or presbycusis, has been associated with large-scale mitochondrial DNA (mtDNA) deletion in previous studies. However, the role of this mtDNA damage in presbycusis is still not clear because the deletion in inner ears has not been measured quantitatively and analyzed in para...

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Bibliographic Details
Main Authors: Shankai Yin, Zhiping Yu, Ravi Sockalingam, Manohar Bance, Genlou Sun, Jian Wang
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001179