Estetrol modulates endothelial nitric oxide synthesis in human endothelial cells

Estetrol (E4) is a natural human estrogen that is present at high concentrations during pregnancy. E4 has been reported to act as an endogenous estrogen receptor modulator, exerting estrogenic actions on the endometrium or the central nervous system but presenting antagonistic effects on the breast....

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Main Authors: Maria Magdalena eMontt-Guevara, Maria Silvia eGiretti, Eleonora eRusso, Andrea eGiannini, Paolo eMannella, Andrea Riccardo Genazzani, Alessandro David Genazzani, Tommaso eSimoncini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00111/full