Alterations of mass density and 3D osteocyte lacunar properties in bisphosphonate-related osteonecrotic human jaw bone, a synchrotron µCT study.

Osteonecrosis of the jaw, in association with bisphosphonates (BRONJ) used for treating osteoporosis or cancer, is a severe and most often irreversible side effect whose underlying pathophysiological mechanisms remain largely unknown. Osteocytes are involved in bone remodeling and mineralization whe...

Full description

Bibliographic Details
Main Authors: Bernhard Hesse, Max Langer, Peter Varga, Alexandra Pacureanu, Pei Dong, Susanne Schrof, Nils Männicke, Heikki Suhonen, Cecile Olivier, Peter Maurer, Galateia J Kazakia, Kay Raum, Francoise Peyrin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586331/?tool=EBI