Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1

Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1

OBJECTIVES: MiRNAs are intrinsic RNAs that interfere with protein translation. Few studies on the synergistic effects of miRNAs have been reported. Both miR-424 and miR-381 have been individually reported to be involved in carcinogenesis. They share a common putative target, WEE1, which is described...

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Bibliographic Details
Main Authors: Binghai Chen, Lujing Duan, Guangming Yin, Jing Tan, Xianzhen Jiang
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2013-06-01
Series:Clinics
Subjects:
miRNA
WEE1
miR-424
miR-381
Synergistic Effect
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000600825

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000600825

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