Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice

Abstract Background Thymosin β4 (Tβ4) is the most abundant member of the β-thymosins and plays an important role in the control of actin polymerization in eukaryotic cells. While its effects in multiple organs and diseases are being widely investigated, the safety profile has been established in ani...

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Bibliographic Details
Main Authors: Meng Wang, Li-Rong Feng, Zi-Long Li, Kai-Ge Ma, Ke-Wei Chang, Xin-Lin Chen, Peng-Bo Yang, Sheng-Feng Ji, Yan-Bing Ma, Hua Han, John Bosco Ruganzua, Wei-Na Yang, Yi-Hua Qian
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
Thymosin β4
Alzheimer’s disease
Cognition and emotion
Phenotypic polarization of glial cells and neuroinflammation
NF-κB signaling pathway
Online Access:https://doi.org/10.1186/s12974-021-02166-3

Internet

https://doi.org/10.1186/s12974-021-02166-3

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