Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice
Abstract Background Thymosin β4 (Tβ4) is the most abundant member of the β-thymosins and plays an important role in the control of actin polymerization in eukaryotic cells. While its effects in multiple organs and diseases are being widely investigated, the safety profile has been established in ani...
Main Authors: | Meng Wang, Li-Rong Feng, Zi-Long Li, Kai-Ge Ma, Ke-Wei Chang, Xin-Lin Chen, Peng-Bo Yang, Sheng-Feng Ji, Yan-Bing Ma, Hua Han, John Bosco Ruganzua, Wei-Na Yang, Yi-Hua Qian |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-06-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-021-02166-3 |
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