Chitosan-Collagen 3D Matrix Mimics Trabecular Bone and Regulates RANKL-Mediated Paracrine Cues of Differentiated Osteoblast and Mesenchymal Stem Cells for Bone Marrow Macrophage-Derived Osteoclastogenesis

Chitosan-Collagen 3D Matrix Mimics Trabecular Bone and Regulates RANKL-Mediated Paracrine Cues of Differentiated Osteoblast and Mesenchymal Stem Cells for Bone Marrow Macrophage-Derived Osteoclastogenesis

Recent studies have identified the regulatory mechanism of collagen in bone ossification and resorption. Due to its excellent bio-mimicry property, collagen is used for the treatment of several bone and joint disease such as arthritis, osteoporosis, and osteopenia. In bone, the biological action of...

Full description

Bibliographic Details
Main Authors: Jeevithan Elango, Kandasamy Saravanakumar, Saeed Ur Rahman, Yves Henrotin, Joe M. Regenstein, Wenhui Wu, Bin Bao
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Biomolecules
Subjects:
chitosan-composite 3D matrix
rheological properties
biomechanical properties
mesenchymal stem cells
osteoclast
ovariectomized mice
RANKL
Runx2
bone homeostasis
Online Access:https://www.mdpi.com/2218-273X/9/5/173

Internet

https://www.mdpi.com/2218-273X/9/5/173

Similar Items