Structural Basis for a Reciprocal Regulation between SCF and CSN

Structural Basis for a Reciprocal Regulation between SCF and CSN

Skp1-Cul1-Fbox (SCF) E3 ligases are activated by ligation to the ubiquitin-like protein Nedd8, which is reversed by the deneddylating Cop9 signalosome (CSN). However, CSN also promotes SCF substrate turnover through unknown mechanisms. Through biochemical and electron microscopy analyses, we determ...

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Bibliographic Details
Main Authors: Radoslav I. Enchev, Daniel C. Scott, Paula C.A. da Fonseca, Anne Schreiber, Julie K. Monda, Brenda A. Schulman, Matthias Peter, Edward P. Morris
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712002598

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http://www.sciencedirect.com/science/article/pii/S2211124712002598

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