Advances in using PARP inhibitors to treat cancer
<p>Abstract</p> <p>The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with ove...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-03-01
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| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1741-7015/10/25 |