Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials.

Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials.

Three phase 2b, double-blind, placebo-controlled, randomized efficacy trials have tested recombinant Adenovirus serotype-5 (rAd5)-vector preventive HIV-1 vaccines: MRKAd5 HIV-1 gag/pol/nef in Step and Phambili, and DNA/rAd5 HIV-1 env/gag/pol in HVTN505. Due to efficacy futility observed at the first...

Full description

Bibliographic Details
Main Authors: Yunda Huang, Dean Follmann, Martha Nason, Lily Zhang, Ying Huang, Devan V Mehrotra, Zoe Moodie, Barbara Metch, Holly Janes, Michael C Keefer, Gavin Churchyard, Merlin L Robb, Patricia E Fast, Ann Duerr, M Juliana McElrath, Lawrence Corey, John R Mascola, Barney S Graham, Magdalena E Sobieszczyk, James G Kublin, Michael Robertson, Scott M Hammer, Glenda E Gray, Susan P Buchbinder, Peter B Gilbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4558095?pdf=render

Internet

http://europepmc.org/articles/PMC4558095?pdf=render

Similar Items