MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT

MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT

Abstract Background Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone (P4) inhibits proliferation by coordinating stromal-epithelial cross-ta...

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Bibliographic Details
Main Authors: Jung-Yoon Yoo, Hee-Bum Kang, Russell R. Broaddus, John I. Risinger, Kyung-Chul Choi, Tae Hoon Kim
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cancer
Subjects:
MIG-6
Progesterone resistance
Endometrial hyperplasia
AKT
Online Access:http://link.springer.com/article/10.1186/s12885-018-4502-7

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http://link.springer.com/article/10.1186/s12885-018-4502-7

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