Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

Angiotensin II (AII) plays a major role in the progression of inflammation and NADPH-derived oxidative stress (OS) in several tissues. The brain possesses a local angiotensin system, and OS and inflammation are key factors in the progression of Parkinson's disease. In rat mesencephalic cultures...

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Bibliographic Details
Main Authors: J. Rodriguez-Pallares, P. Rey, J.A. Parga, A. Muñoz, M.J Guerra, J.L. Labandeira-Garcia
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000533