Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death

Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death

Human neuroblastoma SH-SY5Y cells are a widely-used human neuronal cell model in the study of neurodegeneration. A recent study shows that, 1-methyl-4-phenylpyridine ion (MPP), which selectively causes dopaminergic neuronal death leading to Parkinson’s disease-like symptoms, can reduce SH-...

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Bibliographic Details
Main Authors: Xinfang An, Zixing Fu, Chendi Mai, Weiming Wang, Linyu Wei, Dongliang Li, Chaokun Li, Lin-Hua Jiang
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
human neuroblastoma SH-SY5Y cells
TRPM2 channel
ROS
neuronal cell death
Online Access:http://www.mdpi.com/2073-4409/8/1/28

Internet

http://www.mdpi.com/2073-4409/8/1/28

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