A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy with other PDGFRα ligands might obscure additional...

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Bibliographic Details
Main Authors: Johanna Andrae, Leonor Gouveia, Radiosa Gallini, Liqun He, Linda Fredriksson, Ingrid Nilsson, Bengt R. Johansson, Ulf Eriksson, Christer Betsholtz
Format: Article
Language:English
Published: The Company of Biologists 2016-04-01
Series:Biology Open
Subjects:
PDGF-C
Meninges
Basement membrane
Cerebrum
PDGFRα
Online Access:http://bio.biologists.org/content/5/4/461

Internet

http://bio.biologists.org/content/5/4/461

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