Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces. Here we show that knockout mice of Shootin1 display abnormal projection of the forebrain commissural...

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Bibliographic Details
Main Authors: Kentarou Baba, Wataru Yoshida, Michinori Toriyama, Tadayuki Shimada, Colleen F Manning, Michiko Saito, Kenji Kohno, James S Trimmer, Rikiya Watanabe, Naoyuki Inagaki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
axon guidance
chemotaxis
growth cone
gradient sensing
shootin1
clutch
Online Access:https://elifesciences.org/articles/34593

Internet

https://elifesciences.org/articles/34593

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