Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Influenza-induced lung edema and inflammation are exacerbated by a positive feedback loop of cytokine and chemokine production termed a 'cytokine storm', a hallmark of increased influenza-related morbidity and mortality. Upon infection, an immune response is rapidly initiated in the lungs...

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Bibliographic Details
Main Authors: Melanie P Matheu, John R Teijaro, Kevin B Walsh, Milton L Greenberg, David Marsolais, Ian Parker, Hugh Rosen, Michael B A Oldstone, Michael D Cahalan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3606384?pdf=render

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http://europepmc.org/articles/PMC3606384?pdf=render

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