Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

During development, pyramidal neurons undergo dynamic regulation of AMPA receptor (AMPAR) subunit composition and density to help drive synaptic plasticity and maturation. These normal developmental changes in AMPARs are particularly vulnerable to risk factors for Autism Spectrum Disorders (ASDs), w...

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Bibliographic Details
Main Authors: Huong T. T. Ha, Sergio Leal-Ortiz, Kriti Lalwani, Shigeki Kiyonaka, Itaru Hamachi, Shreesh P. Mysore, Johanna M. Montgomery, Craig C. Garner, John R. Huguenard, Sally A. Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
zinc signaling
AMPA receptor (AMPAR)
GluA2 (GluR2)
GluA1 (GluR1)
Shank2
Shank3
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00405/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00405/full

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