Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors and effectors in immune defence. Upon binding to the membrane, they convert from the soluble monomeric form to oligome...

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Bibliographic Details
Main Authors: Carl Leung, Natalya V Dudkina, Natalya Lukoyanova, Adrian W Hodel, Irene Farabella, Arun P Pandurangan, Nasrin Jahan, Mafalda Pires Damaso, Dino Osmanović, Cyril F Reboul, Michelle A Dunstone, Peter W Andrew, Rana Lonnen, Maya Topf, Helen R Saibil, Bart W Hoogenboom
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-12-01
Series:eLife
Subjects:
cholesterol-dependent cytolysin
bacterial toxin
membrane pore formation
pore-forming protein
S. suis
Online Access:https://elifesciences.org/articles/04247

Internet

https://elifesciences.org/articles/04247

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