Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors

Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors

Inducible nitric oxide synthase (iNOS) produces NO from l-arginine and plays critical roles in inflammation and immune activation. Selective and potent iNOS inhibitors may be potentially used in many indications, such as rheumatoid arthritis, pain, and neurodegeration. In the current study, five new...

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Bibliographic Details
Main Authors: Hong Pu, Jianxin Liu, Yeji Wang, Yuhui Peng, Wanying Zheng, Yang Tang, Boping Hui, Chunmei Nie, Xueshuang Huang, Yanwen Duan, Yong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
endophytic fungus
Diaporthe sp.
α-pyrone
anti-inflammation
inducible nitric oxide synthase
NO
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.679592/full

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https://www.frontiersin.org/articles/10.3389/fchem.2021.679592/full

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