Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta <i>Arenicola marina</i>, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization

Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta <i>Arenicola marina</i>, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization

Arenicin-1, a &#946;-sheet antimicrobial peptide isolated from the marine polychaeta <i>Arenicola marina</i> coelomocytes, has a potent, broad-spectrum microbicidal activity and also shows significant toxicity towards mammalian cells. Several variants were rationally designed to eluc...

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Bibliographic Details
Main Authors: Dmitriy S. Orlov, Olga V. Shamova, Igor E. Eliseev, Maria S. Zharkova, Oleg B. Chakchir, Nikolinka Antcheva, Sotir Zachariev, Pavel V. Panteleev, Vladimir N. Kokryakov, Tatiana V. Ovchinnikova, Alessandro Tossi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Marine Drugs
Subjects:
marine peptides
arenicin-1
molecular symmetry
structure–activity relationship
antibacterial
cytotoxic
chemical synthesis
molecular dynamics
Online Access:https://www.mdpi.com/1660-3397/17/6/376

Internet

https://www.mdpi.com/1660-3397/17/6/376

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