Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P

Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P

Abstract Background The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, SP/NK-1R interactions have been associated with severe neuroinflammation and neuronal damag...

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Bibliographic Details
Main Authors: Amanda R. Burmeister, M. Brittany Johnson, Vinita S. Chauhan, Megan J. Moerdyk-Schauwecker, Ada D. Young, Ian D. Cooley, Alejandra N. Martinez, Geeta Ramesh, Mario T. Philipp, Ian Marriott
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Neuroinflammation
Subjects:
Substance P
Neurokinin-1 receptor
Neuroinflammation
Human
Microglia
Astrocyte
Online Access:http://link.springer.com/article/10.1186/s12974-017-1012-5

Internet

http://link.springer.com/article/10.1186/s12974-017-1012-5

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