3′UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function

3′UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function

FUS is an RNA-binding protein associated with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Previous reports have demonstrated intrinsic roles of FUS in synaptic function. However, the mechanism underlying FUS’s regulation of synaptic morphology has remained uncle...

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Bibliographic Details
Main Authors: Satoshi Yokoi, Tsuyoshi Udagawa, Yusuke Fujioka, Daiyu Honda, Haruo Okado, Hirohisa Watanabe, Masahisa Katsuno, Shinsuke Ishigaki, Gen Sobue
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
FUS
SynGAP1
FTLD
fronto-temporal lobar degeneration
ALS
spine maturation
cognitive function
ELAV-like protein
mRNA stability
3′UTR
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312603

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http://www.sciencedirect.com/science/article/pii/S2211124717312603

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