Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain

Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain

A limiting factor in brain research still is the difficulty to evaluate in vivo the role of the increasing number of proteins implicated in neuronal processes. We discuss here the potential of antisense-mediated RNA targeting approaches. We mainly focus on those that manipulate splicing (exon skippi...

Full description

Bibliographic Details
Main Authors: Ioannis eZalachoras, Melvin M Evers, Willeke M C van Roon-Mom, Annemieke M Aartsma-Rus, Onno C Meijer
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Gene Expression
Mutagenesis
Toxicity
siRNA
delivery
exon skipping
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00010/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00010/full

Similar Items