Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain

Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain

A limiting factor in brain research still is the difficulty to evaluate in vivo the role of the increasing number of proteins implicated in neuronal processes. We discuss here the potential of antisense-mediated RNA targeting approaches. We mainly focus on those that manipulate splicing (exon skippi...

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Bibliographic Details
Main Authors:	Ioannis eZalachoras, Melvin M Evers, Willeke M C van Roon-Mom, Annemieke M Aartsma-Rus, Onno C Meijer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2011-07-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	Gene Expression Mutagenesis Toxicity siRNA delivery exon skipping
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00010/full

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