Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's Tumorigenesis

Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's Tumorigenesis

Chronic gastroesophageal reflux disease is a known risk factor for Barrett's esophagus (BE), that induces oxidative mucosal damage. Glutathione peroxidase-3 (GPx3) is a secretory protein with potent extracellular antioxidant activity. Herein, we have investigated the mRNA, protein expression o...

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Bibliographic Details
Main Authors: Ok-Jae Lee, Regine Schneider-Stock, Patricia A. McChesney, Doerthe Kuester, Albert Roessner, Michael Vieth, Christopher A. Moskaluk, Wa'el El-Rifai
Format: Article
Language:English
Published: Elsevier 2005-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Barrett's
dysplasia
cancer
GPx3
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800077

Internet

http://www.sciencedirect.com/science/article/pii/S1476558605800077

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