SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-α Signaling

SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-α Signaling

The transcription factor sex determining region (Y SRY)-box 2 (SOX2) is known to play a crucial role in the maintenance of self renewal or pluripotency of undifferentiated embryonic and neuronal stem cells. An elevated expression of SOX2 has been correlated with poor prognosis of esophageal squamous...

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Bibliographic Details
Main Authors: Hui Gao, Chunyuan Teng, Wenjing Huang, Jianjun Peng, Chunbo Wang
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
SOX2
esophageal squamous cell carcinoma
Slug
metastasis
EMT (epithelial to mesenchymal transition)
Online Access:http://www.mdpi.com/1422-0067/16/9/21643

Internet

http://www.mdpi.com/1422-0067/16/9/21643

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