Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the immune response. IMPDH reversibly polymerizes in cells and tissues in response to changes in metabolic demand. Self-assembly of...

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Bibliographic Details
Main Authors: Matthew C Johnson, Justin M Kollman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
Cryo-EM
metabolism
purine
enzyme filament
allostery
Online Access:https://elifesciences.org/articles/53243

Internet

https://elifesciences.org/articles/53243

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