Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophagesResearch in context

Background: Chronic heavy alcohol drinking (CHD) leads to significant organ damage, increased susceptibility to infections, and delayed wound healing. These adverse outcomes are believed to be mediated by alterations in the function of myeloid cells; however, the mechanisms underlying these changes...

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Bibliographic Details
Main Authors: Suhas Sureshchandra, Cara Stull, Brian Jin Kee Ligh, Selene Bich Nguyen, Kathleen A. Grant, Ilhem Messaoudi
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641930266X